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Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.

Science (New York, N.Y.) | Dec 23, 2005

Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.

Pubmed ID: 16373578 RIS Download

Mesh terms: Animals | Biotin | Catalysis | Cell Line | Cyclooxygenase 2 | Cysteine | Dinoprostone | Enzyme Activation | Humans | Mice | Nitric Oxide Donors | Nitric Oxide Synthase Type II | Nitroso Compounds | Protein Binding | S-Nitrosoglutathione

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Associated grants

  • Agency: NIDA NIH HHS, Id: DA000266
  • Agency: NIDA NIH HHS, Id: DA00074

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