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Generation and characterization of Sca2 (ataxin-2) knockout mice.

Ataxin-2, the gene product of the Spinocerebellar Ataxia Type 2 (SCA2) gene, is a protein of unknown function with abundant expression in embryonic and adult tissues. Its interaction with A2BP1/Fox-1, a protein with an RNA recognition motif, suggests involvement of ataxin-2 in mRNA translation or transport. To study the effects of in vivo ataxin-2 function, we generated an ataxin-2 deficient mouse strain. Ataxin-2 deficient mice were viable. Genotypic analysis of litters from mating of heterozygous mice showed segregation distortion with a significant reduction in the birth of Sca-/- females. Detailed macroscopic and microscopic analysis of surviving nullizygous Sca2 knockout mice showed no major histological abnormalities. On a fat-enriched diet, ataxin-2 deficient animals had increased weight gain. Our results demonstrate that ataxin-2, although widely expressed, is not essential in development or during adult survival in the mouse, but leads to adult-onset obesity.

Pubmed ID: 16293225


  • Kiehl TR
  • Nechiporuk A
  • Figueroa KP
  • Keating MT
  • Huynh DP
  • Pulst SM


Biochemical and biophysical research communications

Publication Data

January 6, 2006

Associated Grants

  • Agency: NINDS NIH HHS, Id: R01-NS33123

Mesh Terms

  • Animals
  • Animals, Newborn
  • Female
  • Male
  • Mice
  • Mice, Knockout
  • Motor Activity
  • Nerve Tissue Proteins
  • Obesity
  • Organ Specificity