IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.
Cytokines of the interleukin-1 (IL-1) family, such as IL-1 alpha/beta and IL-18, have important functions in host defense, immune regulation, and inflammation. Insight into their biological functions has led to novel therapeutic approaches to treat human inflammatory diseases. Within the IL-1 family, IL-1 alpha/beta, IL-1Ra, and IL-18 have been matched to their respective receptor complexes and have been shown to have distinct biological functions. The most prominent orphan IL-1 receptor is ST 2. This receptor has been described as a negative regulator of Toll-like receptor-IL-1 receptor signaling, but it also functions as an important effector molecule of T helper type 2 responses. We report a member of the IL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.
Pubmed ID: 16286016 RIS Download
Amino Acid Sequence | Animals | Cell Differentiation | Cell Polarity | Cytokines | Enzyme Activation | Eosinophils | Gene Expression Regulation | Humans | Interleukins | Mast Cells | Membrane Proteins | Mice | Mitogen-Activated Protein Kinases | Molecular Sequence Data | NF-kappa B | Phosphorylation | Phylogeny | Receptors, Cell Surface | Receptors, Interleukin | Receptors, Interleukin-1 | Sequence Alignment | Sequence Homology, Amino Acid | Signal Transduction | Spleen | Th2 Cells