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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.

PLoS medicine | 2005

The proteases (secretases) that cleave amyloid-beta (Abeta) peptide from the amyloid precursor protein (APP) have been the focus of considerable investigation in the development of treatments for Alzheimer disease. The prediction has been that reducing Abeta production in the brain, even after the onset of clinical symptoms and the development of associated pathology, will facilitate the repair of damaged tissue and removal of amyloid lesions. However, no long-term studies using animal models of amyloid pathology have yet been performed to test this hypothesis.

Pubmed ID: 16279840 RIS Download

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Associated grants

  • Agency: NIA NIH HHS, United States
    Id: R01 AG006656
  • Agency: NIA NIH HHS, United States
    Id: K01 AG026144-02
  • Agency: NIA NIH HHS, United States
    Id: P50 AG005146
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS047225
  • Agency: NIA NIH HHS, United States
    Id: K01 AG026144-05
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS 047225
  • Agency: NIA NIH HHS, United States
    Id: K01 AG026144
  • Agency: NIA NIH HHS, United States
    Id: P50 AGO5146-20
  • Agency: NIA NIH HHS, United States
    Id: P01 AG015453
  • Agency: NIA NIH HHS, United States
    Id: K01 AG026144-04
  • Agency: NIA NIH HHS, United States
    Id: R01 AG006656-16
  • Agency: NIA NIH HHS, United States
    Id: K01 AG026144-01
  • Agency: NIA NIH HHS, United States
    Id: K01 AG26144-01
  • Agency: NIA NIH HHS, United States
    Id: K01 AG026144-03

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Alzheimers Association (tool)

RRID:SCR_007398

A non profit organization dedicated to providing support for patients and families with Alzheimer's disease, to educating the public about the disease, to funding a wide range of Alzheimer's disease related research and to finding ways to treat and eventually to prevent Alzheimer's disease. Resources include: the Alzheimer's Association Green-Field Library, a research grants program, and the Journal of the Alzheimer's Association.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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