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Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane.

Developmental cell | Sep 13, 2005

The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane. Furthermore, Rab11 and Armadillo interact with the exocyst components Sec15 and Sec10, respectively. Our results support a model whereby the exocyst regulates DE-Cadherin trafficking, from recycling endosomes to sites on the epithelial cell membrane where Armadillo is located.

Pubmed ID: 16224820 RIS Download

Mesh terms: Animals | Armadillo Domain Proteins | Cadherins | Carrier Proteins | Cell Membrane | Drosophila | Drosophila Proteins | Endosomes | Epithelial Cells | Exocytosis | Membrane Proteins | Models, Biological | Oocytes | Protein Transport | Trans-Activators | Transcription Factors | Vesicular Transport Proteins

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