We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Astrocytic purinergic signaling coordinates synaptic networks.

Science (New York, N.Y.) | Oct 7, 2005

To investigate the role of astrocytes in regulating synaptic transmission, we generated inducible transgenic mice that express a dominant-negative SNARE domain selectively in astrocytes to block the release of transmitters from these glial cells. By releasing adenosine triphosphate, which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission, thereby enhancing the dynamic range for long-term potentiation and mediated activity-dependent, heterosynaptic depression. These results indicate that astrocytes are intricately linked in the regulation of synaptic strength and plasticity and provide a pathway for synaptic cross-talk.

Pubmed ID: 16210541 RIS Download

Mesh terms: Adenosine | Adenosine A1 Receptor Antagonists | Adenosine Triphosphatases | Adenosine Triphosphate | Animals | Astrocytes | Cells, Cultured | Excitatory Postsynaptic Potentials | Hippocampus | In Vitro Techniques | Long-Term Potentiation | Mice | Mice, Transgenic | Neuronal Plasticity | Purinergic P1 Receptor Antagonists | Purinergic P2 Receptor Antagonists | Receptor, Adenosine A1 | Receptors, N-Methyl-D-Aspartate | Receptors, Purinergic P1 | Receptors, Purinergic P2 | Synapses | Synaptic Transmission | Xanthines