Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2.

C5L2 is an enigmatic serpentine receptor that is co-expressed with the C5a receptor on many cells including polymorphonuclear neutrophils. The apparent absence of coupling of C5L2 with G proteins suggests that this receptor may modulate the biological activity of C5a, perhaps by acting as a decoy receptor. Alternatively, C5L2 may affect C5a function through formation of a heteromeric complex with the C5aR, or it may utilize a G protein-independent signaling pathway. Here we show that in mice bearing a targeted deletion of C5L2, the biological activity of C5a/C5a(desArg) is enhanced both in vivo and in vitro. The biological role of C5L2 thus appears to be limiting to the pro-inflammatory response to the anaphylatoxin. Accordingly, up-regulation of C5L2 may be of benefit in inflammatory states driven by C5a, including sepsis, asthma, cystic fibrosis, and chronic obstructive lung disease.

Pubmed ID: 16204243


  • Gerard NP
  • Lu B
  • Liu P
  • Craig S
  • Fujiwara Y
  • Okinaga S
  • Gerard C


The Journal of biological chemistry

Publication Data

December 2, 2005

Associated Grants

  • Agency: NHLBI NIH HHS, Id: HL36162
  • Agency: NHLBI NIH HHS, Id: HL69511

Mesh Terms

  • Anaphylatoxins
  • Animals
  • Anti-Inflammatory Agents
  • Bone Marrow Cells
  • Chemotaxis
  • Cloning, Molecular
  • Complement C5a
  • DNA, Complementary
  • Female
  • GTP-Binding Proteins
  • Gene Expression Regulation
  • Inflammation
  • Interleukin-6
  • Lung
  • Lung Injury
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Models, Genetic
  • Neutrophils
  • Phenotype
  • Protein Binding
  • RNA, Messenger
  • Receptors, Chemokine
  • Recombinant Proteins
  • Tumor Necrosis Factor-alpha
  • Up-Regulation