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G2D: a tool for mining genes associated with disease.

BMC genetics | Aug 22, 2005

BACKGROUND: Human inherited diseases can be associated by genetic linkage with one or more genomic regions. The availability of the complete sequence of the human genome allows examining those locations for an associated gene. We previously developed an algorithm to prioritize genes on a chromosomal region according to their possible relation to an inherited disease using a combination of data mining on biomedical databases and gene sequence analysis. RESULTS: We have implemented this method as a web application in our site G2D (Genes to Diseases). It allows users to inspect any region of the human genome to find candidate genes related to a genetic disease of their interest. In addition, the G2D server includes pre-computed analyses of candidate genes for 552 linked monogenic diseases without an associated gene, and the analysis of 18 asthma loci. CONCLUSION: G2D can be publicly accessed at

Pubmed ID: 16115313 RIS Download

Mesh terms: Algorithms | Alzheimer Disease | Asthma | Genetic Diseases, Inborn | Genetic Linkage | Genetic Predisposition to Disease | Humans | Internet