Literature search services are currently unavailable. During our hosting provider's UPS upgrade we experienced a hardware failure and are currently working to resolve the issue.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Conditional telomerase induction causes proliferation of hair follicle stem cells.

TERT, the protein component of telomerase, serves to maintain telomere function through the de novo addition of telomere repeats to chromosome ends, and is reactivated in 90% of human cancers. In normal tissues, TERT is expressed in stem cells and in progenitor cells, but its role in these compartments is not fully understood. Here we show that conditional transgenic induction of TERT in mouse skin epithelium causes a rapid transition from telogen (the resting phase of the hair follicle cycle) to anagen (the active phase), thereby facilitating robust hair growth. TERT overexpression promotes this developmental transition by causing proliferation of quiescent, multipotent stem cells in the hair follicle bulge region. This new function for TERT does not require the telomerase RNA component, which encodes the template for telomere addition, and therefore operates through a mechanism independent of its activity in synthesizing telomere repeats. These data indicate that, in addition to its established role in extending telomeres, TERT can promote proliferation of resting stem cells through a non-canonical pathway.

Pubmed ID: 16107853


  • Sarin KY
  • Cheung P
  • Gilison D
  • Lee E
  • Tennen RI
  • Wang E
  • Artandi MK
  • Oro AE
  • Artandi SE



Publication Data

August 18, 2005

Associated Grants

  • Agency: NCI NIH HHS, Id: K08 CA082176
  • Agency: NCI NIH HHS, Id: R55 CA109088

Mesh Terms

  • Animals
  • Bromodeoxyuridine
  • Cell Proliferation
  • DNA-Binding Proteins
  • Enzyme Induction
  • Hair Follicle
  • Mice
  • Mice, Transgenic
  • RNA
  • Stem Cells
  • Telomerase
  • Transgenes