Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Fast adaptation in vestibular hair cells requires myosin-1c activity.

Neuron | Aug 18, 2005

http://www.ncbi.nlm.nih.gov/pubmed/16102537

In sensory hair cells of the inner ear, mechanical amplification of small stimuli requires fast adaptation, the rapid closing of mechanically activated transduction channels. In frog and mouse vestibular hair cells, we found that the rate of fast adaptation depends on both channel opening and stimulus size and that it is modeled well as a release of a mechanical element in series with the transduction apparatus. To determine whether myosin-1c molecules of the adaptation motor are responsible for the release, we introduced the Y61G mutation into the Myo1c locus and generated mice homozygous for this sensitized allele. Measuring transduction and adaptation in the presence of NMB-ADP, an allele-specific inhibitor, we found that the inhibitor not only blocked slow adaptation, as demonstrated previously in transgenic mice, but also inhibited fast adaptation. These results suggest that mechanical activity of myosin-1c is required for fast adaptation in vestibular hair cells.

Pubmed ID: 16102537 RIS Download

Mesh terms: Adaptation, Physiological | Alleles | Animals | Anura | Hair Cells, Vestibular | Mechanotransduction, Cellular | Membrane Potentials | Mice | Mice, Transgenic | Mutation | Myosin Type I | Myosins | Patch-Clamp Techniques | Postural Balance | Protein Synthesis Inhibitors | Reaction Time | Time Factors

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIDCD NIH HHS, Id: P30 DC005983
  • Agency: NIDCD NIH HHS, Id: R01 DC002368
  • Agency: NIDCD NIH HHS, Id: R01 DC003279
  • Agency: NIDCD NIH HHS, Id: R01 DC005439
  • Agency: NIDCD NIH HHS, Id: R01 DC005439
  • Agency: NIDCD NIH HHS, Id: R01 DC005439-04

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.