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Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells.

Vertebrate T cells express either an alpha beta or gamma delta T cell receptor (TCR). The developmental relatedness of the two cell types is unresolved. alpha beta + T cells respond to specific pathogens by collaborating with immunoglobulin-producing B cells in distinct lymphoid organs such as the spleen and Peyer's patches. The precise influence of alpha beta + T cells on B cell development is poorly understood. To investigate the developmental effects of alpha beta + T cells on B cells and gamma delta + T cells, mice homozygous for a disrupted TCR alpha gene were generated. The homozygotes showed elimination of alpha beta + T cells and the loss of thymic medullae. Despite this, gamma delta + T cells developed in normal numbers, and there was an increase in splenic B cells.

Pubmed ID: 1604321

Authors

  • Philpott KL
  • Viney JL
  • Kay G
  • Rastan S
  • Gardiner EM
  • Chae S
  • Hayday AC
  • Owen MJ

Journal

Science (New York, N.Y.)

Publication Data

June 5, 1992

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM37759

Mesh Terms

  • Animals
  • B-Lymphocytes
  • Blastocyst
  • Blotting, Southern
  • Chimera
  • Clone Cells
  • DNA
  • Female
  • Lymphoid Tissue
  • Macromolecular Substances
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Mutant Strains
  • Peyer's Patches
  • Polymerase Chain Reaction
  • Receptors, Antigen, T-Cell
  • Spleen
  • T-Lymphocytes
  • Thymus Gland