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Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells.

Science (New York, N.Y.) | Jun 5, 1992

Vertebrate T cells express either an alpha beta or gamma delta T cell receptor (TCR). The developmental relatedness of the two cell types is unresolved. alpha beta + T cells respond to specific pathogens by collaborating with immunoglobulin-producing B cells in distinct lymphoid organs such as the spleen and Peyer's patches. The precise influence of alpha beta + T cells on B cell development is poorly understood. To investigate the developmental effects of alpha beta + T cells on B cells and gamma delta + T cells, mice homozygous for a disrupted TCR alpha gene were generated. The homozygotes showed elimination of alpha beta + T cells and the loss of thymic medullae. Despite this, gamma delta + T cells developed in normal numbers, and there was an increase in splenic B cells.

Pubmed ID: 1604321 RIS Download

Mesh terms: Animals | B-Lymphocytes | Blastocyst | Blotting, Southern | Chimera | Clone Cells | DNA | Female | Lymphoid Tissue | Macromolecular Substances | Male | Mice | Mice, Inbred BALB C | Mice, Mutant Strains | Peyer's Patches | Polymerase Chain Reaction | Receptors, Antigen, T-Cell | Spleen | T-Lymphocytes | Thymus Gland

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM37759

Mouse Genome Informatics (Data, Gene Annotation)

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