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The genome of the kinetoplastid parasite, Leishmania major.

Ivens AC | Peacock CS | Worthey EA | Murphy L | Aggarwal G | Berriman M | Sisk E | Rajandream MA | Adlem E | Aert R | Anupama A | Apostolou Z | Attipoe P | Bason N | Bauser C | Beck A | Beverley SM | Bianchettin G | Borzym K | Bothe G | Bruschi CV | Collins M | Cadag E | Ciarloni L | Clayton C | Coulson RM | Cronin A | Cruz AK | Davies RM | De Gaudenzi J | Dobson DE | Duesterhoeft A | Fazelina G | Fosker N | Frasch AC | Fraser A | Fuchs M | Gabel C | Goble A | Goffeau A | Harris D | Hertz-Fowler C | Hilbert H | Horn D | Huang Y | Klages S | Knights A | Kube M | Larke N | Litvin L | Lord A | Louie T | Marra M | Masuy D | Matthews K | Michaeli S | Mottram JC | Müller-Auer S | Munden H | Nelson S | Norbertczak H | Oliver K | O'neil S | Pentony M | Pohl TM | Price C | Purnelle B | Quail MA | Rabbinowitsch E | Reinhardt R | Rieger M | Rinta J | Robben J | Robertson L | Ruiz JC | Rutter S | Saunders D | Schäfer M | Schein J | Schwartz DC | Seeger K | Seyler A | Sharp S | Shin H | Sivam D | Squares R | Squares S | Tosato V | Vogt C | Volckaert G | Wambutt R | Warren T | Wedler H | Woodward J | Zhou S | Zimmermann W | Smith DF | Blackwell JM | Stuart KD | Barrell B | Myler PJ
Science (New York, N.Y.) | Jul 15, 2005

http://www.ncbi.nlm.nih.gov/pubmed/16020728

Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.

Pubmed ID: 16020728 RIS Download

Mesh terms: Animals | Chromatin | Gene Expression Regulation | Genes, Protozoan | Genes, rRNA | Genome, Protozoan | Glycoconjugates | Leishmania major | Leishmaniasis, Cutaneous | Lipid Metabolism | Membrane Proteins | Molecular Sequence Data | Multigene Family | Protein Biosynthesis | Protein Processing, Post-Translational | Protozoan Proteins | RNA Processing, Post-Transcriptional | RNA Splicing | RNA, Protozoan | Sequence Analysis, DNA | Transcription, Genetic