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Effects of age on volumes of cortex, white matter and subcortical structures.

The effect of age was investigated in and compared across 16 automatically segmented brain measures: cortical gray matter, cerebral white matter, hippocampus, amygdala, thalamus, the accumbens area, caudate, putamen, pallidum, brainstem, cerebellar cortex, cerebellar white matter, the lateral ventricle, the inferior lateral ventricle, and the 3rd and 4th ventricle. Significant age effects were found for all volumes except pallidum and the 4th ventricle. Heterogeneous age responses were seen in that age relationships for cortex, amygdala, thalamus, the accumbens area, and caudate were linear, while cerebral white matter, hippocampus, brainstem, cerebellar white, and gray matter, as well as volume of the lateral, inferior lateral, and 3rd ventricles showed curvilinear relationships with age. In general, the findings point to global and large effects of age across brain volumes.

Pubmed ID: 16005549


  • Walhovd KB
  • Fjell AM
  • Reinvang I
  • Lundervold A
  • Dale AM
  • Eilertsen DE
  • Quinn BT
  • Salat D
  • Makris N
  • Fischl B


Neurobiology of aging

Publication Data

October 26, 2005

Associated Grants

  • Agency: NCRR NIH HHS, Id: P41-RR14075
  • Agency: NINDS NIH HHS, Id: R01-NS39581
  • Agency: NCRR NIH HHS, Id: R01-RR13609
  • Agency: NCRR NIH HHS, Id: R01-RR16594

Mesh Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Brain Mapping
  • Cerebral Cortex
  • Female
  • Functional Laterality
  • Humans
  • Image Processing, Computer-Assisted
  • Lateral Ventricles
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neural Pathways
  • Regression Analysis
  • Statistics, Nonparametric