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Extension of murine life span by overexpression of catalase targeted to mitochondria.

To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria (MCAT). Median and maximum life spans were maximally increased (averages of 5 months and 5.5 months, respectively) in MCAT animals. Cardiac pathology and cataract development were delayed, oxidative damage was reduced, H2O2 production and H2O2-induced aconitase inactivation were attenuated, and the development of mitochondrial deletions was reduced. These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals.

Pubmed ID: 15879174


  • Schriner SE
  • Linford NJ
  • Martin GM
  • Treuting P
  • Ogburn CE
  • Emond M
  • Coskun PE
  • Ladiges W
  • Wolf N
  • Van Remmen H
  • Wallace DC
  • Rabinovitch PS


Science (New York, N.Y.)

Publication Data

June 24, 2005

Associated Grants

  • Agency: NIA NIH HHS, Id: AG001751
  • Agency: NIA NIH HHS, Id: AG13280
  • Agency: NIEHS NIH HHS, Id: ES07033

Mesh Terms

  • Aconitate Hydratase
  • Aging
  • Animals
  • Arteriosclerosis
  • Catalase
  • Cataract
  • Cell Nucleus
  • DNA
  • Deoxyguanosine
  • Female
  • Free Radicals
  • Heart Diseases
  • Humans
  • Hydrogen Peroxide
  • Longevity
  • Male
  • Mice
  • Mice, Transgenic
  • Mitochondria
  • Mitochondria, Heart
  • Muscle, Skeletal
  • Myocardium
  • Oxidation-Reduction
  • Oxidative Stress
  • Peroxisomes
  • Reactive Oxygen Species
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction
  • Superoxide Dismutase