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Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver.

Solute carrier family 11, member 2 (SLC11A2) is the only transmembrane iron transporter known to be involved in cellular iron uptake. It is widely expressed and has been postulated to play important roles in intestinal iron absorption, erythroid iron utilization, hepatic iron accumulation, placental iron transfer, and other processes. Previous studies have suggested that other transporters might exist, but their physiological significance remained uncertain. To define the activities of Slc11a2 in vivo, we inactivated the murine gene that encodes it globally and selectively. We found that fetal Slc11a2 is not needed for materno-fetal iron transfer but that Slc11a2 activity is essential for intestinal non-heme iron absorption after birth. Slc11a2 is also required for normal hemoglobin production during the development of erythroid precursors. However, hepatocytes and most other cells must have an alternative, as-yet-unknown, iron uptake mechanism. We previously showed that Slc11a2 serves as the primary portal for intestinal iron entry in hemochromatosis. However, inactivation of murine Hfe ameliorates the phenotype of animals lacking Slc11a2.

Pubmed ID: 15849611


  • Gunshin H
  • Fujiwara Y
  • Custodio AO
  • Direnzo C
  • Robine S
  • Andrews NC


The Journal of clinical investigation

Publication Data

May 2, 2005

Associated Grants

  • Agency: NIDDK NIH HHS, Id: K01 DK02804
  • Agency: NIDDK NIH HHS, Id: P30 DK49216
  • Agency: NICHD NIH HHS, Id: P30 HD18655
  • Agency: NIDDK NIH HHS, Id: R01 DK053813
  • Agency: NIDDK NIH HHS, Id: R01 DK053813-10
  • Agency: NIDDK NIH HHS, Id: R01 DK53813

Mesh Terms

  • Animals
  • Cation Transport Proteins
  • Erythropoiesis
  • Female
  • Genes, Reporter
  • Heterozygote
  • Homozygote
  • Integrases
  • Intestine, Small
  • Iron
  • Iron-Binding Proteins
  • Liver
  • Mice
  • Mice, Transgenic
  • Placenta
  • Pregnancy
  • Promoter Regions, Genetic