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Gaze fixation and the neural circuitry of face processing in autism.

Nature neuroscience | Apr 29, 2005

Diminished gaze fixation is one of the core features of autism and has been proposed to be associated with abnormalities in the neural circuitry of affect. We tested this hypothesis in two separate studies using eye tracking while measuring functional brain activity during facial discrimination tasks in individuals with autism and in typically developing individuals. Activation in the fusiform gyrus and amygdala was strongly and positively correlated with the time spent fixating the eyes in the autistic group in both studies, suggesting that diminished gaze fixation may account for the fusiform hypoactivation to faces commonly reported in autism. In addition, variation in eye fixation within autistic individuals was strongly and positively associated with amygdala activation across both studies, suggesting a heightened emotional response associated with gaze fixation in autism.

Pubmed ID: 15750588 RIS Download

Mesh terms: Adolescent | Analysis of Variance | Autistic Disorder | Brain | Brain Mapping | Case-Control Studies | Discrimination (Psychology) | Emotions | Facial Expression | Fixation, Ocular | Functional Laterality | Humans | Image Processing, Computer-Assisted | Magnetic Resonance Imaging | Male | Nerve Net | Neuropsychological Tests | Pattern Recognition, Visual | Photic Stimulation | Reaction Time | Task Performance and Analysis

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Associated grants

  • Agency: NICHD NIH HHS, Id: P30 HD003352
  • Agency: NIMH NIH HHS, Id: U54 MH066398
  • Agency: NICHD NIH HHS, Id: T32 HD007489
  • Agency: NIMH NIH HHS, Id: R01 MH069793
  • Agency: NIMH NIH HHS, Id: U54MH066398
  • Agency: NICHD NIH HHS, Id: P30 HD03352
  • Agency: NICHD NIH HHS, Id: T32 HD07489

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