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Mammalian SAD kinases are required for neuronal polarization.

Science (New York, N.Y.) | Feb 11, 2005

http://www.ncbi.nlm.nih.gov/pubmed/15705853

Electrical activity in neurons is generally initiated in dendritic processes then propagated along axons to synapses, where it is passed to other neurons. Major structural features of neurons-their dendrites and axons-are thus related to their fundamental functions: the receipt and transmission of information. The acquisition of these distinct properties by dendrites and axons, called polarization, is a critical step in neuronal differentiation. We show here that SAD-A and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization. These kinases will provide entry points for unraveling signaling mechanisms that polarize neurons.

Pubmed ID: 15705853 RIS Download

Mesh terms: Animals | Apoptosis | Axons | Brain | Brain Chemistry | Cell Differentiation | Cell Line | Cell Polarity | Cell Shape | Cells, Cultured | Cerebral Cortex | Dendrites | Hippocampus | Mice | Microtubule-Associated Proteins | Mutation | Neurons | Phosphorylation | Prosencephalon | Protein-Serine-Threonine Kinases | Spinal Cord | tau Proteins

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