Our hosting provider will be performing UPS maintenance on Tuesday, Oct 25, 2016 between 8 AM and 5 PM PDT. SciCrunch searching services will be down during this time.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.


CD8+ T cells require a signal through a costimulatory receptor in addition to TCR engagement to become activated. The role of CD28 in costimulating T cell activation is well established. NKG2D, a receptor found on NK cells, CD8+ alphabeta-TCR+ T cells, and gammadelta-TCR+ T cells, has also been implicated in T cell costimulation. In this study we have evaluated the role of NKG2D in costimulating mouse and human naive and effector CD8+ T cells. Unexpectedly, in contrast to CD28, NKG2D engagement by ligand or mAb is not sufficient to costimulate naive or effector CD8+ T cell responses in conventional T cell populations. While NKG2D did not costimulate CD8+ T cells on its own, it was able to modify CD28-mediated costimulation of human CD8+ T cells under certain contitions. It is, therefore, likely that NKG2D acts as a costimulatory molecule only under restricted conditions or requires additional cofactors.

Pubmed ID: 15699119


  • Ehrlich LI
  • Ogasawara K
  • Hamerman JA
  • Takaki R
  • Zingoni A
  • Allison JP
  • Lanier LL


Journal of immunology (Baltimore, Md. : 1950)

Publication Data

February 15, 2005

Associated Grants

  • Agency: NCI NIH HHS, Id: CA89189
  • Agency: NCI NIH HHS, Id: CA95137

Mesh Terms

  • Adjuvants, Immunologic
  • Animals
  • Antibodies, Monoclonal
  • Antigens, CD28
  • CD8-Positive T-Lymphocytes
  • Cell Line, Tumor
  • Cells, Cultured
  • Coculture Techniques
  • Cross-Linking Reagents
  • Cytotoxicity Tests, Immunologic
  • G0 Phase
  • Humans
  • Interferon-gamma
  • Ligands
  • Lymphocyte Activation
  • Melanoma, Experimental
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mice, Transgenic
  • NK Cell Lectin-Like Receptor Subfamily K
  • Receptors, Antigen, T-Cell
  • Receptors, Immunologic
  • Receptors, Natural Killer Cell