Our hosting provider will be undergoing maintenance on Tuesday, August 30 between 8am and 5pm PDT. SciCrunch services may be offline during the maintenance.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing.

Variants of NOD2, an intracellular sensor of bacteria-derived muramyl dipeptide (MDP), increase susceptibility to Crohn's disease (CD). These variants are thought to be defective in activation of nuclear factor kappaB (NF-kappaB) and antibacterial defenses, but CD clinical specimens display elevated NF-kappaB activity. To illuminate the pathophysiological function of NOD2, we introduced such a variant to the mouse Nod2 locus. Mutant mice exhibited elevated NF-kappaB activation in response to MDP and more efficient processing and secretion of the cytokine interleukin-1beta (IL-1beta). These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion.

Pubmed ID: 15692052

Authors

  • Maeda S
  • Hsu LC
  • Liu H
  • Bankston LA
  • Iimura M
  • Kagnoff MF
  • Eckmann L
  • Karin M

Journal

Science (New York, N.Y.)

Publication Data

February 4, 2005

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI43477
  • Agency: NIAID NIH HHS, Id: AI56075
  • Agency: NIDDK NIH HHS, Id: DK07202
  • Agency: NIDDK NIH HHS, Id: DK35108

Mesh Terms

  • Acetylmuramyl-Alanyl-Isoglutamine
  • Animals
  • Anti-Bacterial Agents
  • Apoptosis
  • Bacteria
  • Cells, Cultured
  • Colitis
  • Colon
  • Crohn Disease
  • Cytokines
  • Dextran Sulfate
  • Interleukin-1
  • Intestinal Mucosa
  • Intracellular Signaling Peptides and Proteins
  • Lipopolysaccharides
  • Macrophage Activation
  • Macrophages
  • Mice
  • Mutation
  • NF-kappa B
  • Nod2 Signaling Adaptor Protein
  • Peptidoglycan
  • Signal Transduction