We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Anticonvulsant medications extend worm life-span.

Science (New York, N.Y.) | Jan 14, 2005

Genetic studies have elucidated mechanisms that regulate aging, but there has been little progress in identifying drugs that delay aging. Here, we report that ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes, indicating that these compounds retard the aging process. These compounds, two of which are approved for human use, are anticonvulsants that modulate neural activity. These compounds also regulated neuromuscular activity in nematodes. These findings suggest that the life-span-extending activity of these compounds is related to the anticonvulsant activity and implicate neural activity in the regulation of aging.

Pubmed ID: 15653505 RIS Download

Mesh terms: Aging | Aldicarb | Animals | Anticonvulsants | Caenorhabditis elegans | Caenorhabditis elegans Proteins | Disorders of Sex Development | Dose-Response Relationship, Drug | Drug Evaluation, Preclinical | Epilepsy, Absence | Ethosuximide | Female | Forkhead Transcription Factors | Genes, Helminth | Humans | Lactams | Longevity | Movement | Muscles | Mutation | Neurons | Oviposition | Pharynx | Reproduction | Synaptic Transmission | Transcription Factors | Trimethadione | Vulva

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.