• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.

Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its approximately 20-megabase genome, which contains approximately 6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.

Pubmed ID: 15653466


  • Loftus BJ
  • Fung E
  • Roncaglia P
  • Rowley D
  • Amedeo P
  • Bruno D
  • Vamathevan J
  • Miranda M
  • Anderson IJ
  • Fraser JA
  • Allen JE
  • Bosdet IE
  • Brent MR
  • Chiu R
  • Doering TL
  • Donlin MJ
  • D'Souza CA
  • Fox DS
  • Grinberg V
  • Fu J
  • Fukushima M
  • Haas BJ
  • Huang JC
  • Janbon G
  • Jones SJ
  • Koo HL
  • Krzywinski MI
  • Kwon-Chung JK
  • Lengeler KB
  • Maiti R
  • Marra MA
  • Marra RE
  • Mathewson CA
  • Mitchell TG
  • Pertea M
  • Riggs FR
  • Salzberg SL
  • Schein JE
  • Shvartsbeyn A
  • Shin H
  • Shumway M
  • Specht CA
  • Suh BB
  • Tenney A
  • Utterback TR
  • Wickes BL
  • Wortman JR
  • Wye NH
  • Kronstad JW
  • Lodge JK
  • Heitman J
  • Davis RW
  • Fraser CM
  • Hyman RW


Science (New York, N.Y.)

Publication Data

February 25, 2005

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI47087
  • Agency: NIAID NIH HHS, Id: AI48594
  • Agency: NIAID NIH HHS, Id: R01 AI050184
  • Agency: NIAID NIH HHS, Id: R01 AI050184-05
  • Agency: NHLBI NIH HHS, Id: R01 HL088905
  • Agency: NHLBI NIH HHS, Id: R01 HL088905-04A2

Mesh Terms

  • Alternative Splicing
  • Cell Wall
  • Chromosomes, Fungal
  • Computational Biology
  • Cryptococcus neoformans
  • DNA Transposable Elements
  • Fungal Proteins
  • Gene Library
  • Genes, Fungal
  • Genome, Fungal
  • Humans
  • Introns
  • Molecular Sequence Data
  • Phenotype
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Polysaccharides
  • RNA, Antisense
  • Sequence Analysis, DNA
  • Transcription, Genetic
  • Virulence
  • Virulence Factors