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Sex but no hand difference in the isthmus of the corpus callosum.

We performed high-resolution magnetic resonance morphometry of the total midsagittal area and seven midsagittal subareas of the corpus callosum in healthy young adult dextrals and sinistrals (N = 52). There was no influence of handedness on these anatomic measurements. However, an effect of sex emerged, with women (N = 26) having a larger proportional isthmus segment of the callosum. This may reflect a sex-specific difference in the interhemispheric connectivity and functional organization of the temporoparietal association cortex.

Pubmed ID: 1565226


  • Steinmetz H
  • J√§ncke L
  • Kleinschmidt A
  • Schlaug G
  • Volkmann J
  • Huang Y



Publication Data

April 20, 1992

Associated Grants


Mesh Terms

  • Adult
  • Analysis of Variance
  • Corpus Callosum
  • Female
  • Functional Laterality
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Multivariate Analysis
  • Sex Characteristics