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The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.

The multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase (HAT) complex performs critical functions in a variety of cellular processes including transcriptional activation, double strand DNA break repair, and apoptosis. We previously isolated the TRRAP/TIP60 complex from HeLa cells (Cai, Y., Jin, J., Tomomori-Sato, C., Sato, S., Sorokina, I., Parmely, T. J., Conaway, R. C., and Conaway, J. W. (2003) J. Biol. Chem. 278, 42733-42736). Analysis of proteins present in preparations of the TRRAP/TIP60 complex led to the identification of several new subunits, as well as several potential subunits including the YL1 protein. Here we present evidence that the YL1 protein is a previously unrecognized subunit of the TRRAP/TIP60 HAT complex. In addition, we present evidence that YL1 is also a component of a novel mammalian multiprotein complex that includes the SNF2-related helicase SRCAP and resembles the recently described Saccharomyces cerevisiae SWR1 chromatin remodeling complex. Taken together, our findings identify the YL1 protein as a new subunit of the TRRAP/TIP60 HAT complex, and they suggest that YL1 plays multiple roles in chromatin modification and remodeling in cells.

Pubmed ID: 15647280


  • Cai Y
  • Jin J
  • Florens L
  • Swanson SK
  • Kusch T
  • Li B
  • Workman JL
  • Washburn MP
  • Conaway RC
  • Conaway JW


The Journal of biological chemistry

Publication Data

April 8, 2005

Associated Grants

  • Agency: NIGMS NIH HHS, Id: R37 GM41628

Mesh Terms

  • Acetyltransferases
  • Adaptor Proteins, Signal Transducing
  • Adenosine Triphosphatases
  • Animals
  • DNA-Binding Proteins
  • HeLa Cells
  • Histone Acetyltransferases
  • Humans
  • Multiprotein Complexes
  • Nuclear Proteins
  • Protein Subunits
  • Repressor Proteins