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Morphogenetic and cellular movements that shape the mouse cerebellum; insights from genetic fate mapping.

We used the cerebellum as a model to study the morphogenetic and cellular processes underlying the formation of elaborate brain structures from a simple neural tube, using an inducible genetic fate mapping approach in mouse. We demonstrate how a 90 degrees rotation between embryonic days 9 and 12 converts the rostral-caudal axis of dorsal rhombomere 1 into the medial-lateral axis of the wing-like bilateral cerebellar primordium. With the appropriate use of promoters, we marked specific medial-lateral domains of the cerebellar primordium and derived a positional fate map of the murine cerebellum. We show that the adult medial cerebellum is produced by expansion, rather than fusion, of the thin medial primordium. Furthermore, ventricular-derived cells maintain their original medial-lateral coordinates into the adult, whereas rhombic lip-derived granule cells undergo lateral to medial posterior transverse migrations during foliation. Thus, we show that progressive changes in the axes of the cerebellum underlie its genesis.

Pubmed ID: 15629700

Authors

  • Sgaier SK
  • Millet S
  • Villanueva MP
  • Berenshteyn F
  • Song C
  • Joyner AL

Journal

Neuron

Publication Data

January 6, 2005

Associated Grants

None

Mesh Terms

  • Animals
  • Body Patterning
  • Cell Differentiation
  • Cell Lineage
  • Cell Movement
  • Cerebellum
  • Chimera
  • Female
  • Gene Expression Regulation, Developmental
  • Genetic Markers
  • Homeodomain Proteins
  • Integrases
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Morphogenesis
  • Nerve Tissue Proteins
  • Neurons
  • Promoter Regions, Genetic
  • Stem Cells