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Androgen receptor coregulator ARA267-alpha interacts with death receptor-6 revealed by the yeast two-hybrid.

ARA267-alpha is a newly identified androgen receptor coactivator. In order to further elucidate its precise role in cells, using the ARA267-alpha fragment containing four PHD and one SET conserved domains as bait we revealed an ARA267-alpha-PHD-SET-interacting protein, death receptor-6 (DR6), in the yeast two-hybrid screening. DR6 is the member of TNF receptor family and has a death domain in its intracellular cytoplasmic portion (DR6cp) to mediate the cell apoptosis. The interaction between ARA267-alpha-PHD-SET and DR6cp was confirmed in vitro and in vivo. Our finding implied that androgen signaling pathway might cross talk with apoptosis signaling pathway through the interaction between ARA267-alpha and DR6.

Pubmed ID: 15623156


  • Mai T
  • Wang X
  • Zhang Z
  • Xin D
  • Na Y
  • Guo Y


Science in China. Series C, Life sciences / Chinese Academy of Sciences

Publication Data

October 29, 2004

Associated Grants


Mesh Terms

  • Animals
  • Blotting, Western
  • Cell Line, Tumor
  • Cloning, Molecular
  • DNA, Complementary
  • Escherichia coli
  • Humans
  • Immunoprecipitation
  • Intracellular Signaling Peptides and Proteins
  • Mice
  • Nuclear Proteins
  • Plasmids
  • Protein Binding
  • Protein Structure, Tertiary
  • Receptors, Androgen
  • Receptors, Tumor Necrosis Factor
  • Signal Transduction
  • Two-Hybrid System Techniques