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Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth.

Cancer cell | Dec 20, 2004

http://www.ncbi.nlm.nih.gov/pubmed/15607964

p53-dependent apoptosis is a major determinant of its tumor suppressor activity and can be triggered by hypoxia. No p53 target is known to be induced by p53 or to mediate p53-dependent apoptosis during hypoxia. We report that p53 can directly upregulate expression of Bnip3L, a cell death inducer. During hypoxia, Bnip3L is highly induced in wild-type p53-expressing cells, in part due to increased recruitment of p53 and CBP to Bnip3L. Apoptosis is reduced in hypoxia-exposed cells with functional p53 following Bnip3L knockdown. In vivo, Bnip3L knockdown promotes tumorigenicity of wild-type versus mutant p53-expressing tumors. Thus, Bnip3L, capable of attenuating tumorigenicity, mediates p53-dependent apoptosis under hypoxia, which provides a novel understanding of p53 in tumor suppression.

Pubmed ID: 15607964 RIS Download

Mesh terms: Animals | Apoptosis | Blotting, Western | CREB-Binding Protein | Caspase 3 | Caspases | Cell Hypoxia | Cell Line, Tumor | Cell Proliferation | Chromatin Immunoprecipitation | Cisplatin | Doxycycline | Fluorouracil | Gene Expression Regulation, Neoplastic | Genes, Reporter | Glucose Transporter Type 1 | Humans | Immunohistochemistry | In Situ Hybridization | Membrane Proteins | Mice | Mice, Nude | Monosaccharide Transport Proteins | Neoplasms | Nuclear Proteins | Oligonucleotide Array Sequence Analysis | Protein Binding | Proto-Oncogene Proteins | RNA Interference | RNA, Small Interfering | Repressor Proteins | Trans-Activators | Transfection | Tumor Suppressor Protein p53 | Tumor Suppressor Proteins | Xenograft Model Antitumor Assays

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Associated grants

  • Agency: NCI NIH HHS, Id: CA105008
  • Agency: NCI NIH HHS, Id: CA75138
  • Agency: NCI NIH HHS, Id: CA75454

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