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Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.

Wnt signaling plays a crucial role in a number of developmental processes and in tumorigenesis. beta-Catenin is stabilized by Wnt signaling and associates with the TCF/LEF family of transcription factors, thereby activating transcription of Wnt target genes. Constitutive activation of beta-catenin-TCF-mediated transcription resulting from mutations in adenomatous polyposis coli (APC), beta-catenin, or Axin is believed to be a critical step in tumorigenesis among divergent types of cancers. Here we show that the transactivation potential of the beta-catenin-TCF complex is enhanced by its interaction with a BCL9-like protein, B9L, in addition to BCL9. We found that B9L is required for enhanced beta-catenin-TCF-mediated transcription in colorectal tumor cells and for beta-catenin-induced transformation of RK3E cells. Furthermore, expression of B9L was aberrantly elevated in about 43% of colorectal tumors, relative to the corresponding noncancerous tissues. These results suggest that B9L plays an important role in tumorigenesis induced by aberrant activation of Wnt signaling.

Pubmed ID: 15574752


  • Adachi S
  • Jigami T
  • Yasui T
  • Nakano T
  • Ohwada S
  • Omori Y
  • Sugano S
  • Ohkawara B
  • Shibuya H
  • Nakamura T
  • Akiyama T


Cancer research

Publication Data

December 1, 2004

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Cell Transformation, Neoplastic
  • Colorectal Neoplasms
  • Cytoskeletal Proteins
  • DNA-Binding Proteins
  • Humans
  • Immunohistochemistry
  • Intercellular Signaling Peptides and Proteins
  • Lymphoid Enhancer-Binding Factor 1
  • Molecular Sequence Data
  • Neoplasm Proteins
  • Protein Binding
  • Rats
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction
  • Trans-Activators
  • Transcription Factors
  • Transcription, Genetic
  • Transfection
  • Wnt Proteins
  • beta Catenin