• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.

Wnt signaling plays a crucial role in a number of developmental processes and in tumorigenesis. beta-Catenin is stabilized by Wnt signaling and associates with the TCF/LEF family of transcription factors, thereby activating transcription of Wnt target genes. Constitutive activation of beta-catenin-TCF-mediated transcription resulting from mutations in adenomatous polyposis coli (APC), beta-catenin, or Axin is believed to be a critical step in tumorigenesis among divergent types of cancers. Here we show that the transactivation potential of the beta-catenin-TCF complex is enhanced by its interaction with a BCL9-like protein, B9L, in addition to BCL9. We found that B9L is required for enhanced beta-catenin-TCF-mediated transcription in colorectal tumor cells and for beta-catenin-induced transformation of RK3E cells. Furthermore, expression of B9L was aberrantly elevated in about 43% of colorectal tumors, relative to the corresponding noncancerous tissues. These results suggest that B9L plays an important role in tumorigenesis induced by aberrant activation of Wnt signaling.

Pubmed ID: 15574752

Authors

  • Adachi S
  • Jigami T
  • Yasui T
  • Nakano T
  • Ohwada S
  • Omori Y
  • Sugano S
  • Ohkawara B
  • Shibuya H
  • Nakamura T
  • Akiyama T

Journal

Cancer research

Publication Data

December 1, 2004

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Cell Transformation, Neoplastic
  • Colorectal Neoplasms
  • Cytoskeletal Proteins
  • DNA-Binding Proteins
  • Humans
  • Immunohistochemistry
  • Intercellular Signaling Peptides and Proteins
  • Lymphoid Enhancer-Binding Factor 1
  • Molecular Sequence Data
  • Neoplasm Proteins
  • Protein Binding
  • Rats
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction
  • Trans-Activators
  • Transcription Factors
  • Transcription, Genetic
  • Transfection
  • Wnt Proteins
  • beta Catenin