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Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development.

The aryl hydrocarbon receptor (AHR) is commonly known for its role in the adaptive metabolism of xenobiotics and in the toxic events that follow exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). Previously, we have demonstrated that the AHR and its heterodimeric partner, the AHR nuclear translocator (ARNT), play a role in the developmental closure of a hepatic vascular shunt known as the ductus venosus (DV). To investigate the mechanism of DV closure, we generated hypomorphic alleles of the Ahr and Arnt loci. Using these models, we then asked whether this vascular defect could be rescued by receptor activation during late development. By manipulating gestational exposure, the patent DV in AHR or ARNT hypomorphs could be efficiently closed by dioxin exposure as early as embryonic day 12.5 and as late as embryonic day 18.5. These findings define the temporal regulation of receptor activation during normal ontogeny and provide evidence to support the idea that receptor activation and AHR-ARNT heterodimerization are essential for normal vascular development. Taken in the broader context, these data demonstrate that similar AHR signaling steps govern all major aspects of AHR biology.

Pubmed ID: 15545609 RIS Download

Mesh terms: Animals | Aryl Hydrocarbon Receptor Nuclear Translocator | Basic Helix-Loop-Helix Transcription Factors | Blood Vessels | DNA-Binding Proteins | Female | Gestational Age | Liver | Male | Mice | Mice, Inbred C57BL | Mice, Inbred DBA | Mice, Knockout | Mice, Mutant Strains | Models, Biological | Phenotype | Polychlorinated Dibenzodioxins | Pregnancy | Receptors, Aryl Hydrocarbon | Signal Transduction | Transcription Factors

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Associated grants

  • Agency: NCI NIH HHS, Id: P01 CA022484
  • Agency: NIEHS NIH HHS, Id: ES006883
  • Agency: NCI NIH HHS, Id: P30 CA014520
  • Agency: NCI NIH HHS, Id: CA014520
  • Agency: NIEHS NIH HHS, Id: R01 ES006883
  • Agency: NCI NIH HHS, Id: CA022484

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