• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

Pubmed ID: 15537879

Authors

  • Pezawas L
  • Verchinski BA
  • Mattay VS
  • Callicott JH
  • Kolachana BS
  • Straub RE
  • Egan MF
  • Meyer-Lindenberg A
  • Weinberger DR

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

November 10, 2004

Associated Grants

None

Mesh Terms

  • Adolescent
  • Adult
  • Alleles
  • Amino Acid Substitution
  • Brain-Derived Neurotrophic Factor
  • Female
  • Genetic Variation
  • Hippocampus
  • Humans
  • Imaging, Three-Dimensional
  • Learning
  • Magnetic Resonance Imaging
  • Male
  • Memory
  • Middle Aged
  • Neuronal Plasticity
  • Organ Size
  • Polymorphism, Genetic
  • Prefrontal Cortex