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The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

Pubmed ID: 15537879


  • Pezawas L
  • Verchinski BA
  • Mattay VS
  • Callicott JH
  • Kolachana BS
  • Straub RE
  • Egan MF
  • Meyer-Lindenberg A
  • Weinberger DR


The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

November 10, 2004

Associated Grants


Mesh Terms

  • Adolescent
  • Adult
  • Alleles
  • Amino Acid Substitution
  • Brain-Derived Neurotrophic Factor
  • Female
  • Genetic Variation
  • Hippocampus
  • Humans
  • Imaging, Three-Dimensional
  • Learning
  • Magnetic Resonance Imaging
  • Male
  • Memory
  • Middle Aged
  • Neuronal Plasticity
  • Organ Size
  • Polymorphism, Genetic
  • Prefrontal Cortex