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Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.

Nature immunology | Nov 21, 2004

http://www.ncbi.nlm.nih.gov/pubmed/15475959

Expression of the transcription factor GATA-3 is strongly associated with T helper type 2 (T(H)2) differentiation, but genetic evidence for its involvement in this process has been lacking. Here, we generated a conditional GATA-3-deficient mouse line. In vitro deletion of Gata3 diminished both interleukin 4 (IL-4)-dependent and IL-4-independent T(H)2 cell differentiation; without GATA-3, T(H)1 differentiation occurred in the absence of IL-12 and interferon-gamma. Gata3 deletion limited the growth of T(H)2 cells but not T(H)1 cells. Deletion of Gata3 from established T(H)2 cells abolished IL-5 and IL-13 but not IL-4 production. In vivo deletion of Gata3 using OX40-Cre eliminated T(H)2 responses and allowed the development of interferon-gamma-producing cells in mice infected with Nippostrongylus brasiliensis. Thus, GATA-3 serves as a principal switch in determining T(H)1-T(H)2 responses.

Pubmed ID: 15475959 RIS Download

Mesh terms: Animals | Cell Differentiation | Cell Division | DNA-Binding Proteins | GATA3 Transcription Factor | Gene Deletion | Mice | Th1 Cells | Th2 Cells | Trans-Activators

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