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Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.

Expression of the transcription factor GATA-3 is strongly associated with T helper type 2 (T(H)2) differentiation, but genetic evidence for its involvement in this process has been lacking. Here, we generated a conditional GATA-3-deficient mouse line. In vitro deletion of Gata3 diminished both interleukin 4 (IL-4)-dependent and IL-4-independent T(H)2 cell differentiation; without GATA-3, T(H)1 differentiation occurred in the absence of IL-12 and interferon-gamma. Gata3 deletion limited the growth of T(H)2 cells but not T(H)1 cells. Deletion of Gata3 from established T(H)2 cells abolished IL-5 and IL-13 but not IL-4 production. In vivo deletion of Gata3 using OX40-Cre eliminated T(H)2 responses and allowed the development of interferon-gamma-producing cells in mice infected with Nippostrongylus brasiliensis. Thus, GATA-3 serves as a principal switch in determining T(H)1-T(H)2 responses.

Pubmed ID: 15475959


  • Zhu J
  • Min B
  • Hu-Li J
  • Watson CJ
  • Grinberg A
  • Wang Q
  • Killeen N
  • Urban JF
  • Guo L
  • Paul WE


Nature immunology

Publication Data

November 21, 2004

Associated Grants


Mesh Terms

  • Animals
  • Cell Differentiation
  • Cell Division
  • DNA-Binding Proteins
  • GATA3 Transcription Factor
  • Gene Deletion
  • Mice
  • Th1 Cells
  • Th2 Cells
  • Trans-Activators