Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Dosage-sensitive requirement for mouse Dll4 in artery development.

Genes & development | Oct 15, 2004

http://www.ncbi.nlm.nih.gov/pubmed/15466159

Involvement of the Notch signaling pathway in vascular development has been demonstrated by both gain- and loss-of-function mutations in humans, mice, and zebrafish. In zebrafish, Notch signaling is required for arterial identity by suppressing the venous fate in developing artery cells. In mice, the Notch4 receptor and the Delta-like 4 (Dll4) ligand are specifically expressed in arterial endothelial cells, suggesting a similar role. Here we show that the Dll4 ligand alone is required in a dosage-sensitive manner for normal arterial patterning in development. This implicates Dll4 as the specific mammalian endothelial ligand for autocrine endothelial Notch signaling, and suggests that Dll4 may be a suitable target for intervention in arterial angiogenesis.

Pubmed ID: 15466159 RIS Download

Mesh terms: Animals | Arteries | DNA Primers | Endothelial Cells | Gene Dosage | Genotype | Immunohistochemistry | In Situ Hybridization | Intracellular Signaling Peptides and Proteins | Ligands | Membrane Proteins | Mice | Mice, Mutant Strains | Receptors, Notch | Reverse Transcriptase Polymerase Chain Reaction | Signal Transduction

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.