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The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism.

Diatoms are unicellular algae with plastids acquired by secondary endosymbiosis. They are responsible for approximately 20% of global carbon fixation. We report the 34 million-base pair draft nuclear genome of the marine diatom Thalassiosira pseudonana and its 129 thousand-base pair plastid and 44 thousand-base pair mitochondrial genomes. Sequence and optical restriction mapping revealed 24 diploid nuclear chromosomes. We identified novel genes for silicic acid transport and formation of silica-based cell walls, high-affinity iron uptake, biosynthetic enzymes for several types of polyunsaturated fatty acids, use of a range of nitrogenous compounds, and a complete urea cycle, all attributes that allow diatoms to prosper in aquatic environments.

Pubmed ID: 15459382


  • Armbrust EV
  • Berges JA
  • Bowler C
  • Green BR
  • Martinez D
  • Putnam NH
  • Zhou S
  • Allen AE
  • Apt KE
  • Bechner M
  • Brzezinski MA
  • Chaal BK
  • Chiovitti A
  • Davis AK
  • Demarest MS
  • Detter JC
  • Glavina T
  • Goodstein D
  • Hadi MZ
  • Hellsten U
  • Hildebrand M
  • Jenkins BD
  • Jurka J
  • Kapitonov VV
  • Kröger N
  • Lau WW
  • Lane TW
  • Larimer FW
  • Lippmeier JC
  • Lucas S
  • Medina M
  • Montsant A
  • Obornik M
  • Parker MS
  • Palenik B
  • Pazour GJ
  • Richardson PM
  • Rynearson TA
  • Saito MA
  • Schwartz DC
  • Thamatrakoln K
  • Valentin K
  • Vardi A
  • Wilkerson FP
  • Rokhsar DS


Science (New York, N.Y.)

Publication Data

October 1, 2004

Associated Grants


Mesh Terms

  • Adaptation, Physiological
  • Algal Proteins
  • Animals
  • Biological Evolution
  • Cell Nucleus
  • Chromosomes
  • DNA
  • Diatoms
  • Ecosystem
  • Energy Metabolism
  • Genome
  • Iron
  • Light
  • Light-Harvesting Protein Complexes
  • Mitochondria
  • Molecular Sequence Data
  • Nitrogen
  • Photosynthesis
  • Plastids
  • Restriction Mapping
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Silicic Acid
  • Symbiosis
  • Urea