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Defining a link with asthma in mice congenitally deficient in eosinophils.

Eosinophils are often dominant inflammatory cells present in the lungs of asthma patients. Nonetheless, the role of these leukocytes remains poorly understood. We have created a transgenic line of mice (PHIL) that are specifically devoid of eosinophils, but otherwise have a full complement of hematopoietically derived cells. Allergen challenge of PHIL mice demonstrated that eosinophils were required for pulmonary mucus accumulation and the airway hyperresponsiveness associated with asthma. The development of an eosinophil-less mouse now permits an unambiguous assessment of a number of human diseases that have been linked to this granulocyte, including allergic diseases, parasite infections, and tumorigenesis.

Pubmed ID: 15375267

Authors

  • Lee JJ
  • Dimina D
  • Macias MP
  • Ochkur SI
  • McGarry MP
  • O'Neill KR
  • Protheroe C
  • Pero R
  • Nguyen T
  • Cormier SA
  • Lenkiewicz E
  • Colbert D
  • Rinaldi L
  • Ackerman SJ
  • Irvin CG
  • Lee NA

Journal

Science (New York, N.Y.)

Publication Data

September 17, 2004

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI025230
  • Agency: NIAID NIH HHS, Id: AI033043
  • Agency: NIAMS NIH HHS, Id: AR08545
  • Agency: NIAMS NIH HHS, Id: F32 AR008545
  • Agency: NIAMS NIH HHS, Id: F32 AR008545-01
  • Agency: NIAMS NIH HHS, Id: F32 AR008545-02
  • Agency: NIAMS NIH HHS, Id: F32 AR008545-03
  • Agency: NHLBI NIH HHS, Id: HL058723
  • Agency: NHLBI NIH HHS, Id: HL065228
  • Agency: NHLBI NIH HHS, Id: HL10105
  • Agency: NHLBI NIH HHS, Id: HLEB67273
  • Agency: NCRR NIH HHS, Id: NCRR-COBRE P20RR1555
  • Agency: NHLBI NIH HHS, Id: P01-HL67004

Mesh Terms

  • Allergens
  • Animals
  • Asthma
  • Diphtheria Toxin
  • Eosinophil Peroxidase
  • Eosinophils
  • Gene Targeting
  • Leukocyte Count
  • Lung
  • Mice
  • Mice, Transgenic
  • Models, Animal
  • Mucus
  • Ovalbumin
  • Peptide Fragments
  • Peroxidases
  • Respiratory Hypersensitivity