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Sir2-independent life span extension by calorie restriction in yeast.

PLoS biology | Sep 15, 2004

Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit associated with calorie restriction. Deletion of FOB1 and overexpression of SIR2 have been previously found to increase life span by reducing the levels of toxic rDNA circles in aged mother cells. We find that combining calorie restriction with either of these genetic interventions dramatically enhances longevity, resulting in the longest-lived yeast strain reported thus far. Further, calorie restriction results in a greater life span extension in cells lacking both Sir2 and Fob1 than in cells where Sir2 is present. These findings indicate that Sir2 and calorie restriction act in parallel pathways to promote longevity in yeast and, perhaps, higher eukaryotes.

Pubmed ID: 15328540 RIS Download

Mesh terms: Caloric Restriction | Culture Media | DNA, Ribosomal | DNA-Binding Proteins | Databases, Genetic | Gene Deletion | Gene Expression Regulation, Fungal | Genetic Techniques | Histone Deacetylases | Models, Biological | Mutation | Phenotype | Plasmids | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Silent Information Regulator Proteins, Saccharomyces cerevisiae | Sirtuin 2 | Sirtuins | Species Specificity | Time Factors

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Associated grants

  • Agency: NIA NIH HHS, Id: P30 AG013280

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A curated database that provides comprehensive integrated biological information for Saccharomyces cerevisiae along with search and analysis tools to explore these data. SGD allows researchers to discover functional relationships between sequence and gene products in fungi and higher organisms. The SGD also maintains the S. cerevisiae Gene Name Registry, a complete list of all gene names used in S. cerevisiae which includes a set of general guidelines to gene naming. Protein Page provides basic protein information calculated from the predicted sequence and contains links to a variety of secondary structure and tertiary structure resources. Yeast Biochemical Pathways allows users to view and search for biochemical reactions and pathways that occur in S. cerevisiae as well as map expression data onto the biochemical pathways. Literature citations are provided where available.

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