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Tryptophan hydroxylase-2 controls brain serotonin synthesis.

Science (New York, N.Y.) | Jul 9, 2004

http://www.ncbi.nlm.nih.gov/pubmed/15247473

Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is preferentially expressed in the brain. We report a functional (C1473G) single-nucleotide polymorphism in mouse Tph2 that results in the substitution of Pro447 with Arg447 and leads to decreased serotonin levels in PC12 cells. Moreover, in BALB/cJ and DBA/2 mice that are homozygous for the 1473G allele, brain serotonin tissue content and synthesis are reduced in comparison to C57Bl/6 and 129X1/SvJ mice that are homozygous for the 1473C allele. Our data provide direct evidence for a fundamental role of Tph2 in brain serotonin synthesis.

Pubmed ID: 15247473 RIS Download

Mesh terms: Alleles | Amino Acid Sequence | Animals | Brain | Brain Stem | Corpus Striatum | Frontal Lobe | Humans | Mice | Mice, Inbred Strains | Molecular Sequence Data | PC12 Cells | Polymorphism, Single Nucleotide | Rats | Reverse Transcriptase Polymerase Chain Reaction | Serotonin | Transfection | Tryptophan Hydroxylase

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Associated grants

  • Agency: NIMH NIH HHS, Id: MH60451

Mouse Genome Informatics (Data, Gene Annotation)

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