Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development.

http://www.ncbi.nlm.nih.gov/pubmed/15240817

Members of the serum- and glucocorticoid-regulated kinase (SGK) family are important mediators of growth factor and hormone signaling that, like their close relatives in the Akt family, are regulated by lipid products of phosphatidylinositol-3-kinase. SGK3 has been implicated in the control of cell survival and regulation of ion channel activity in cultured cells. To begin to dissect the in vivo functions of SGK3, we generated and characterized Sgk3 null mice. These mice are viable and fertile, and in contrast to mice lacking SGK1 or Akt2, respectively, display normal sodium handling and glucose tolerance. However, although normal at birth, by postpartum day 4 they have begun to display an unexpected defect in hair follicle morphogenesis. The abnormality in hair follicle development is preceded by a defect in proliferation and nuclear accumulation of beta-catenin in hair bulb keratinocytes. Furthermore, in cultured keratinocytes, heterologous expression of SGK3 potently modulates activation of beta-catenin/Lef-1-mediated gene transcription. These data establish a role for SGK3 in normal postnatal hair follicle development, possibly involving effects on beta-catenin/Lef-1-mediated gene transcription.

Pubmed ID: 15240817 RIS Download

Mesh terms: Animals | Animals, Newborn | Apoptosis | Base Sequence | Cell Proliferation | Cells, Cultured | Cytoskeletal Proteins | DNA | DNA-Binding Proteins | Female | Forkhead Transcription Factors | Gene Targeting | Glucose | Hair Follicle | Humans | Immediate-Early Proteins | Keratinocytes | Lymphoid Enhancer-Binding Factor 1 | Male | Mice | Mice, Inbred C57BL | Mice, Knockout | Nuclear Proteins | Protein-Serine-Threonine Kinases | RNA, Messenger | Sodium | Trans-Activators | Transcription Factors | Transcriptional Activation | beta Catenin

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIAMS NIH HHS, Id: AR44341
  • Agency: NIDDK NIH HHS, Id: DK56695

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.