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Comparing adiposity profiles in three mouse models with altered GH signaling.

Three mouse lines with altered growth hormone (GH) signaling were used to study GH's role in adiposity. Dwarf GH receptor knockout mice (GHR -/-) and bovine GH antagonist expressing mice (GHA) had an increased percent body fat with most of the excess fat mass accumulating in the subcutaneous region. Giant bovine GH expressing mice (bGH) had a reduced percent body fat. Only GHA mice consumed significantly more food per body weight. Serum leptin levels were significantly increased in GHA mice and decreased in bGH mice but unchanged in the GHR -/- mice. Interestingly, serum adiponectin levels were significantly increased in the GHR -/- and GHA lines but decreased in bGH mice. These data suggest that suppression or absence of GH action and enhanced GH action indeed have opposite metabolic effects in terms of adiposity. Interestingly, adiponectin levels were positively correlated with previously reported insulin sensitivity of these mice, but also positively correlated with adiposity, which is contrary to findings in other mouse models. Thus, adiponectin levels were negatively correlated with GH function suggesting a role for adiponectin in GH-induced insulin resistance.

Pubmed ID: 15231300


  • Berryman DE
  • List EO
  • Coschigano KT
  • Behar K
  • Kim JK
  • Kopchick JJ


Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

Publication Data

August 2, 2004

Associated Grants

  • Agency: NIDDK NIH HHS, Id: R01 DK080756
  • Agency: NIDDK NIH HHS, Id: U24 DK59635

Mesh Terms

  • Adiponectin
  • Adipose Tissue
  • Animals
  • Body Composition
  • Body Weights and Measures
  • Disease Models, Animal
  • Feeding Behavior
  • Female
  • Growth Hormone
  • Insulin Resistance
  • Intercellular Signaling Peptides and Proteins
  • Leptin
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Obesity
  • Signal Transduction
  • Species Specificity