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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

Faithful segregation of replicated chromosomes is essential for maintenance of genetic stability and seems to be monitored by several mitotic checkpoints. Various components of these checkpoints have been identified in mammals, but their physiological relevance is largely unknown. Here we show that mutant mice with low levels of the spindle assembly checkpoint protein BubR1 develop progressive aneuploidy along with a variety of progeroid features, including short lifespan, cachectic dwarfism, lordokyphosis, cataracts, loss of subcutaneous fat and impaired wound healing. Graded reduction of BubR1 expression in mouse embryonic fibroblasts causes increased aneuploidy and senescence. Male and female mutant mice have defects in meiotic chromosome segregation and are infertile. Natural aging of wild-type mice is marked by decreased expression of BubR1 in multiple tissues, including testis and ovary. These results suggest a role for BubR1 in regulating aging and infertility.

Pubmed ID: 15208629


  • Baker DJ
  • Jeganathan KB
  • Cameron JD
  • Thompson M
  • Juneja S
  • Kopecka A
  • Kumar R
  • Jenkins RB
  • de Groen PC
  • Roche P
  • van Deursen JM


Nature genetics

Publication Data

July 30, 2004

Associated Grants

  • Agency: NIDDK NIH HHS, Id: R01 DK025409
  • Agency: NIDDK NIH HHS, Id: R01 DK058546
  • Agency: NIDDK NIH HHS, Id: R01 DK065830

Mesh Terms

  • Aging
  • Aneuploidy
  • Animals
  • Cell Cycle Proteins
  • Female
  • Infertility, Female
  • Infertility, Male
  • Male
  • Mice
  • Mice, Mutant Strains
  • Phenotype
  • Protein Kinases
  • Protein-Serine-Threonine Kinases