Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Abnormal glucose homeostasis due to chronic hyperresistinemia.

Diabetes | Aug 27, 2004

http://www.ncbi.nlm.nih.gov/pubmed/15189975

Resistin is an adipocyte-secreted protein that circulates at increased levels in obesity. Acute administration of resistin impairs glucose tolerance, but the effects of chronic hyperresistinemia have not been established. Here we describe the generation and characterization of transgenic mice that have high circulating levels of resistin in the setting of normal weight. Fasted blood glucose was higher in resistin-transgenic mice than in their nontransgenic littermates, and glucose tolerance was impaired in the hyperresistinemic mice. Metabolic studies in the setting of a hyperinsulinemic-euglycemic clamp protocol revealed that chronically hyperresistinemic mice have elevated glucose production. This increase in glucose production may be partly explained by increased expression of hepatic phosphoenolpyruvate carboxykinase. Thus, chronic hyperresistinemia impairs normal glucose metabolism.

Pubmed ID: 15189975 RIS Download

Mesh terms: Animals | Blood Glucose | Glucose Clamp Technique | Glucose Tolerance Test | Homeostasis | Hormones, Ectopic | Hyperinsulinism | Insulin | Liver | Mice | Mice, Transgenic | Phosphoenolpyruvate Carboxykinase (ATP) | Prealbumin | Resistin

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIDDK NIH HHS, Id: DK45024
  • Agency: NIDDK NIH HHS, Id: DK48321
  • Agency: NIDDK NIH HHS, Id: DK49210
  • Agency: NIDDK NIH HHS, Id: DK49780
  • Agency: NIDDK NIH HHS, Id: P01 DK49210
  • Agency: NIDDK NIH HHS, Id: P30 DK19525
  • Agency: NIDDK NIH HHS, Id: P60 DK20541

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.