Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.

Neuron | Jun 10, 2004

Molecular and cellular mechanisms for memory consolidation in the cortex are poorly known. To study the relationships between synaptic structure and function in the cortex and consolidation of long-term memory, we have generated transgenic mice in which catalytic activity of PAK, a critical regulator of actin remodeling, is inhibited in the postnatal forebrain. Cortical neurons in these mice displayed fewer dendritic spines and an increased proportion of larger synapses compared to wild-type controls. These alterations in basal synaptic morphology correlated with enhanced mean synaptic strength and impaired bidirectional synaptic modifiability (enhanced LTP and reduced LTD) in the cortex. By contrast, spine morphology and synaptic plasticity were normal in the hippocampus of these mice. Importantly, these mice exhibited specific deficits in the consolidation phase of hippocampus-dependent memory. Thus, our results provide evidence for critical relationships between synaptic morphology and bidirectional modifiability of synaptic strength in the cortex and consolidation of long-term memory.

Pubmed ID: 15182717 RIS Download

Mesh terms: Analysis of Variance | Animals | Animals, Newborn | Behavior, Animal | Blotting, Northern | Blotting, Western | Dendrites | Drug Interactions | Enzyme Activation | Excitatory Amino Acid Agonists | Excitatory Amino Acid Antagonists | Glycine | Hippocampus | Immunohistochemistry | In Situ Hybridization | Long-Term Potentiation | Long-Term Synaptic Depression | Male | Maze Learning | Memory Disorders | Mice | Mice, Inbred C57BL | Mice, Transgenic | Microscopy, Electron | Models, Neurological | Nerve Tissue Proteins | Neurofilament Proteins | Neurons | Prosencephalon | Protein-Serine-Threonine Kinases | Proto-Oncogene Proteins c-myc | Rats | Retention (Psychology) | Silver Staining | Spatial Behavior | Synapses | Synaptophysin | Time Factors | Valine | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid | p21-Activated Kinases

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants


Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.