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Recoverin regulates light-dependent phosphodiesterase activity in retinal rods.

The Journal of general physiology | 2004

The Ca2+-binding protein recoverin may regulate visual transduction in retinal rods and cones, but its functional role and mechanism of action remain controversial. We compared the photoresponses of rods from control mice and from mice in which the recoverin gene was knocked out. Our analysis indicates that Ca2+-recoverin prolongs the dark-adapted flash response and increases the rod's sensitivity to dim steady light. Knockout rods had faster Ca2+ dynamics, indicating that recoverin is a significant Ca2+ buffer in the outer segment, but incorporation of exogenous buffer did not restore wild-type behavior. We infer that Ca2+-recoverin potentiates light-triggered phosphodiesterase activity, probably by effectively prolonging the catalytic activity of photoexcited rhodopsin.

Pubmed ID: 15173221 RIS Download

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Associated grants

  • Agency: NEI NIH HHS, United States
    Id: R01 EY014047-04
  • Agency: NEI NIH HHS, United States
    Id: R01 EY014047
  • Agency: NEI NIH HHS, United States
    Id: R01 EY012703
  • Agency: NEI NIH HHS, United States
    Id: EY12703
  • Agency: NEI NIH HHS, United States
    Id: EY05750
  • Agency: NEI NIH HHS, United States
    Id: R01 EY012944
  • Agency: NEI NIH HHS, United States
    Id: EY14047
  • Agency: NIA NIH HHS, United States
    Id: AG12288
  • Agency: NEI NIH HHS, United States
    Id: EY12944

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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