• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.

The liver provides for long-term energy needs of the body by converting excess carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but there is increasing evidence that glucose also contributes to the coordinated regulation of carbohydrate and fat metabolism in liver by mechanisms that are independent of insulin. In this study, we show that the transcription factor, carbohydrate response element-binding protein (ChREBP), is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo.

Pubmed ID: 15118080

Authors

  • Iizuka K
  • Bruick RK
  • Liang G
  • Horton JD
  • Uyeda K

Journal

Proceedings of the National Academy of Sciences of the United States of America

Publication Data

May 11, 2004

Associated Grants

  • Agency: NHLBI NIH HHS, Id: HL 20948

Mesh Terms

  • Animals
  • Base Sequence
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • DNA Primers
  • DNA-Binding Proteins
  • Glycolysis
  • Insulin
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Transcription Factors