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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.

Nature medicine | May 3, 2004

The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.

Pubmed ID: 15098029 RIS Download

Mesh terms: Animals | Apoptosis | Cocarcinogenesis | Eukaryotic Initiation Factor-4E | Gene Expression | Genes, myc | Lymphoma, B-Cell | Mice | Mice, Transgenic | Protein Kinases | TOR Serine-Threonine Kinases

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Mouse Genome Informatics (Data, Gene Annotation)

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