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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.

The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.

Pubmed ID: 15098029


  • Ruggero D
  • Montanaro L
  • Ma L
  • Xu W
  • Londei P
  • Cordon-Cardo C
  • Pandolfi PP


Nature medicine

Publication Data

May 3, 2004

Associated Grants


Mesh Terms

  • Animals
  • Apoptosis
  • Cocarcinogenesis
  • Eukaryotic Initiation Factor-4E
  • Gene Expression
  • Genes, myc
  • Lymphoma, B-Cell
  • Mice
  • Mice, Transgenic
  • Protein Kinases
  • TOR Serine-Threonine Kinases