Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.

Developmental cell | Apr 7, 2004

http://www.ncbi.nlm.nih.gov/pubmed/15068795

The class A and class B synMuv genes are functionally redundant negative regulators of a Ras signaling pathway that induces C. elegans vulval development. A number of class B synMuv genes encode components of an Rb and histone deacetylase complex that likely acts to repress transcription of genes required for vulval induction. We discovered a new class of synMuv genes that acts redundantly with both the A and B classes of genes in vulval cell-fate determination. These new class C synMuv genes encode TRRAP, MYST family histone acetyltransferase, and Enhancer of Polycomb homologs, which form a putative C. elegans Tip60/NuA4-like histone acetyltransferase complex. A fourth gene with partial class C synMuv properties encodes a homolog of the mammalian SWI/SNF family ATPase p400. Our findings indicate that the coordinated action of two chromatin-modifying complexes, one with histone deacetylase and the other with histone acetyltransferase activity, is important in regulating Ras signaling and specifying cell fates during C. elegans development.

Pubmed ID: 15068795 RIS Download

Mesh terms: Acetyltransferases | Adaptor Proteins, Signal Transducing | Adenosine Triphosphatases | Animals | Caenorhabditis elegans | Caenorhabditis elegans Proteins | Cell Lineage | Chromosomal Proteins, Non-Histone | DNA, Complementary | Female | Gene Expression Regulation, Developmental | Histone Acetyltransferases | Histone Deacetylases | Macromolecular Substances | Membrane Glycoproteins | Molecular Sequence Data | Mutation | Nuclear Proteins | Repressor Proteins | Sequence Homology, Amino Acid | Sequence Homology, Nucleic Acid | Trans-Activators | Transcription Factors | Vulva | ras Proteins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIGMS NIH HHS, Id: GM24663

WormBase (Data, Gene Expression)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.