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A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.

The class A and class B synMuv genes are functionally redundant negative regulators of a Ras signaling pathway that induces C. elegans vulval development. A number of class B synMuv genes encode components of an Rb and histone deacetylase complex that likely acts to repress transcription of genes required for vulval induction. We discovered a new class of synMuv genes that acts redundantly with both the A and B classes of genes in vulval cell-fate determination. These new class C synMuv genes encode TRRAP, MYST family histone acetyltransferase, and Enhancer of Polycomb homologs, which form a putative C. elegans Tip60/NuA4-like histone acetyltransferase complex. A fourth gene with partial class C synMuv properties encodes a homolog of the mammalian SWI/SNF family ATPase p400. Our findings indicate that the coordinated action of two chromatin-modifying complexes, one with histone deacetylase and the other with histone acetyltransferase activity, is important in regulating Ras signaling and specifying cell fates during C. elegans development.

Pubmed ID: 15068795


  • Ceol CJ
  • Horvitz HR


Developmental cell

Publication Data

April 7, 2004

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM24663

Mesh Terms

  • Acetyltransferases
  • Adaptor Proteins, Signal Transducing
  • Adenosine Triphosphatases
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cell Lineage
  • Chromosomal Proteins, Non-Histone
  • DNA, Complementary
  • Female
  • Gene Expression Regulation, Developmental
  • Histone Acetyltransferases
  • Histone Deacetylases
  • Macromolecular Substances
  • Membrane Glycoproteins
  • Molecular Sequence Data
  • Mutation
  • Nuclear Proteins
  • Repressor Proteins
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Trans-Activators
  • Transcription Factors
  • Vulva
  • ras Proteins