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Radial glia serve as neuronal progenitors in all regions of the central nervous system.

Radial glial cells function during CNS development as neural progenitors, although their precise contribution to neurogenesis remains controversial. Recent work has argued that regional differences may exist regarding the neurogenic potential of radial glia. Here, we show that the vast majority of neurons in all brain regions derive from radial glia. Cre/loxP fate mapping and clonal analysis demonstrate that radial glia throughout the CNS serve as neuronal progenitors and that radial glia within different regions of the CNS pass through their neurogenic stage of development at distinct time points. Thus, radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia.

Pubmed ID: 15046721


  • Anthony TE
  • Klein C
  • Fishell G
  • Heintz N



Publication Data

March 25, 2004

Associated Grants


Mesh Terms

  • 5' Flanking Region
  • Animals
  • Biological Markers
  • Body Patterning
  • Carrier Proteins
  • Cell Differentiation
  • Cell Lineage
  • Cell Movement
  • Central Nervous System
  • Clone Cells
  • Fatty Acid-Binding Proteins
  • Fetus
  • Gene Expression Regulation, Developmental
  • Mice
  • Mice, Transgenic
  • Nerve Tissue Proteins
  • Neuroglia
  • Neurons
  • Recombination, Genetic
  • Stem Cells