Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Radial glia serve as neuronal progenitors in all regions of the central nervous system.

Neuron | Mar 25, 2004

Radial glial cells function during CNS development as neural progenitors, although their precise contribution to neurogenesis remains controversial. Recent work has argued that regional differences may exist regarding the neurogenic potential of radial glia. Here, we show that the vast majority of neurons in all brain regions derive from radial glia. Cre/loxP fate mapping and clonal analysis demonstrate that radial glia throughout the CNS serve as neuronal progenitors and that radial glia within different regions of the CNS pass through their neurogenic stage of development at distinct time points. Thus, radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia.

Pubmed ID: 15046721 RIS Download

Mesh terms: 5' Flanking Region | Animals | Biomarkers | Body Patterning | Carrier Proteins | Cell Differentiation | Cell Lineage | Cell Movement | Central Nervous System | Clone Cells | Fatty Acid-Binding Protein 7 | Fatty Acid-Binding Proteins | Fetus | Gene Expression Regulation, Developmental | Mice | Mice, Transgenic | Nerve Tissue Proteins | Neuroglia | Neurons | Recombination, Genetic | Stem Cells