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Regulation of fasted blood glucose by resistin.

The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production. This is partly mediated by activation of adenosine monophosphate-activated protein kinase and decreased expression of gluconeogenic enzymes in the liver. The data thus support a physiological function for resistin in the maintenance of blood glucose during fasting. Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity.

Pubmed ID: 14976316


  • Banerjee RR
  • Rangwala SM
  • Shapiro JS
  • Rich AS
  • Rhoades B
  • Qi Y
  • Wang J
  • Rajala MW
  • Pocai A
  • Scherer PE
  • Steppan CM
  • Ahima RS
  • Obici S
  • Rossetti L
  • Lazar MA


Science (New York, N.Y.)

Publication Data

February 20, 2004

Associated Grants

  • Agency: NIGMS NIH HHS, Id: NIH T32-GM008216
  • Agency: NIDDK NIH HHS, Id: P01 DK49210
  • Agency: NIDDK NIH HHS, Id: P30 DK19525
  • Agency: NIDDK NIH HHS, Id: P60 DK20541

Mesh Terms

  • AMP-Activated Protein Kinases
  • Adipocytes
  • Animals
  • Blood Glucose
  • Body Weight
  • Diet
  • Dietary Fats
  • Fasting
  • Gene Targeting
  • Gluconeogenesis
  • Glucose Tolerance Test
  • Glucose-6-Phosphatase
  • Homeostasis
  • Hormones, Ectopic
  • Insulin
  • Liver
  • Male
  • Mice
  • Multienzyme Complexes
  • Obesity
  • Phosphoenolpyruvate Carboxykinase (GTP)
  • Protein-Serine-Threonine Kinases
  • Recombinant Proteins
  • Resistin
  • Signal Transduction