Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis.

http://www.ncbi.nlm.nih.gov/pubmed/14963232

Neurons of the mammalian CNS are thought to originate from progenitors dividing at the apical surface of the neuroepithelium. Here we use mouse embryos expressing GFP from the Tis21 locus, a gene expressed throughout the neural tube in most, if not all, neuron-generating progenitors, to specifically reveal the cell divisions that produce CNS neurons. In addition to the apical, asymmetric divisions of neuroepithelial (NE) cells that generate another NE cell and a neuron, we find, from the onset of neurogenesis, a second population of progenitors that divide in the basal region of the neuroepithelium and generate two neurons. Basal progenitors are most frequent in the telencephalon, where they outnumber the apically dividing neuron-generating NE cells. Our observations reconcile previous data on the origin and lineage of CNS neurons and show that basal, rather than apical, progenitors are the major source of the neurons of the mammalian neocortex.

Pubmed ID: 14963232 RIS Download

Mesh terms: Aging | Animals | Cell Cycle Proteins | Crosses, Genetic | Embryonic and Fetal Development | Epithelial Cells | Female | Genes, Reporter | Genes, Tumor Suppressor | Green Fluorescent Proteins | Heterozygote | Immediate-Early Proteins | Luminescent Proteins | Male | Mice | Mice, Inbred C57BL | Mice, Transgenic | Microscopy, Video | Mitosis | Neurons | Recombinant Fusion Proteins | Rhombencephalon | Telencephalon | Tumor Suppressor Proteins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.