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PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells.

Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell function. We examined the role of PEST domain-enriched tyrosine phosphatase (PEP) in regulating T cell antigen-receptor function during thymocyte development and peripheral T cell differentiation. Although normal naïve T cell functions were retained in pep-deficient mice, effector/memory T cells demonstrated enhanced activation of Lck. In turn, this resulted in increased expansion and function of the effector/memory T cell pool, which was also associated with spontaneous development of germinal centers and elevated serum antibody levels. These results revealed a central role for PEP in negatively regulating specific aspects of T cell development and function.

Pubmed ID: 14752163

Authors

  • Hasegawa K
  • Martin F
  • Huang G
  • Tumas D
  • Diehl L
  • Chan AC

Journal

Science (New York, N.Y.)

Publication Data

January 30, 2004

Associated Grants

None

Mesh Terms

  • Animals
  • Autoimmunity
  • B-Lymphocytes
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cell Cycle
  • Gene Targeting
  • Germinal Center
  • Hydrogen-Ion Concentration
  • Immunoglobulins
  • Immunologic Memory
  • Lymphocyte Activation
  • Lymphocyte Count
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Phosphorylation
  • Protein Tyrosine Phosphatase, Non-Receptor Type 12
  • Protein Tyrosine Phosphatases
  • Receptors, Antigen, T-Cell
  • Signal Transduction
  • T-Lymphocyte Subsets
  • T-Lymphocytes