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PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells.

Science (New York, N.Y.) | Jan 30, 2004

http://www.ncbi.nlm.nih.gov/pubmed/14752163

Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell function. We examined the role of PEST domain-enriched tyrosine phosphatase (PEP) in regulating T cell antigen-receptor function during thymocyte development and peripheral T cell differentiation. Although normal naïve T cell functions were retained in pep-deficient mice, effector/memory T cells demonstrated enhanced activation of Lck. In turn, this resulted in increased expansion and function of the effector/memory T cell pool, which was also associated with spontaneous development of germinal centers and elevated serum antibody levels. These results revealed a central role for PEP in negatively regulating specific aspects of T cell development and function.

Pubmed ID: 14752163 RIS Download

Mesh terms: Animals | Autoimmunity | B-Lymphocytes | CD4-Positive T-Lymphocytes | CD8-Positive T-Lymphocytes | Cell Cycle | Gene Targeting | Germinal Center | Hydrogen-Ion Concentration | Immunoglobulins | Immunologic Memory | Lymphocyte Activation | Lymphocyte Count | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) | Mice | Mice, Inbred BALB C | Mice, Transgenic | Phosphorylation | Protein Tyrosine Phosphatase, Non-Receptor Type 12 | Protein Tyrosine Phosphatases | Receptors, Antigen, T-Cell | Signal Transduction | T-Lymphocyte Subsets | T-Lymphocytes

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