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TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.

The transporter associated with the antigen processing 1 (TAP1) gene encodes a subunit for a transporter, presumed to be involved in the delivery of peptides across the endoplasmic reticulum membrane to class I molecules. We have generated mice with a disrupted TAP1 gene using embryonic stem cell technology. TAP1-deficient mice are defective in the stable assembly and intracellular transport of class I molecules and consequently show severely reduced levels of surface class I molecules. These properties are strikingly similar to those described for the TAP2 mutant cell line RMA-S. Cells from the TAP1-deficient mice are unable to present cytosolic antigens to class I-restricted cytotoxic T cells. As predicted from the near absence of class I surface expression, TAP1-deficient mice lack CD4-8+ T cells.

Pubmed ID: 1473153

Authors

  • Van Kaer L
  • Ashton-Rickardt PG
  • Ploegh HL
  • Tonegawa S

Journal

Cell

Publication Data

December 24, 1992

Associated Grants

None

Mesh Terms

  • Animals
  • Antigens, CD4
  • Antigens, CD8
  • Base Sequence
  • Cell Line
  • Chimera
  • Gene Expression Regulation
  • Genes, MHC Class I
  • Mice
  • Mice, Transgenic
  • Molecular Sequence Data
  • T-Lymphocytes