Regulation of C. elegans longevity by specific gustatory and olfactory neurons.
The life span of C. elegans is extended by mutations that inhibit the function of sensory neurons. In this study, we show that specific subsets of sensory neurons influence longevity. We find that certain gustatory neurons inhibit longevity, whereas others promote longevity, most likely by influencing insulin/IGF-1 signaling. Olfactory neurons also influence life span, and they act in a distinct pathway that involves the reproductive system. In addition, we find that a putative chemosensory G protein-coupled receptor that is expressed in some of these sensory neurons inhibits longevity. Together our findings imply that the life span of C. elegans is regulated by environmental cues and that these cues are perceived and integrated in a complex and sophisticated fashion by specific chemosensory neurons.
Pubmed ID: 14715134
January 8, 2004
- Agency: NIA NIH HHS, Id: AG11816
- Agency: NIA NIH HHS, Id: F32 AG05860
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Fatty Acids
- Feeding Behavior
- GTP-Binding Protein alpha Subunits, Gi-Go
- Membrane Proteins
- Neurons, Afferent
- Olfactory Receptor Neurons
- Receptor, Insulin
- Signal Transduction